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↓ This week’s edition

RxMnemonic Anticoagulant
Warfarin
Vitamin K Antagonist • Oral Anticoagulant
WAR = war + FARIN = far in
Break warfarin into WAR and FAR IN. Imagine you are far in a long war. The way you win a war is by cutting off the enemy's supply lines, and here the critical supply is vitamin K. Warfarin blocks vitamin K, so the clotting factors never get activated. The war takes place in 1972 to represent factors 2, 7, 9, 10. War far in, block the K supply.
Warfarin pharmacology mnemonic illustration
Anticoagulant WAR = war | FARIN = far in
HOW STEP TESTS IT
1
Warfarin blocks vitamin K epoxide reductase, so the liver can't activate the vitamin K-dependent clotting factors (2, 7, 9, 10) and proteins C and S. Its effect is delayed for days because circulating factors must be degraded first, and it is monitored with PT/INR.
2
Warfarin has a narrow therapeutic window and is metabolized by CYP450; it is teratogenic, so heparin is used in pregnancy instead. Reverse warfarin with vitamin K or PCC.
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Every Monday morning, one new drug lands in your email - just the mnemonic, the story, and the clinical pearl.

Step 02

Read the story

A vivid, memorable image helps you remember the drug's mechanism, receptor, and key contraindications in under 2 minutes.

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Today’s Question
Explanation
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What's inside

Everything Step tests.
Nothing you don't need.

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The mnemonic breakdown - drug name decoded into a memorable anchor

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The story + image - a scene that burns the mechanism into memory

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How Step tests it - the exact clinical scenarios you'll see on exam day

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A practice question - test yourself on last week's drug before you forget

Drugs covered so far

✓ Warfarin✓ Oxybutynin✓ Finasteride✓ Vasopressin✓ Paclitaxel✓ Aliskiren✓ Allopurinol✓ Digoxin✓ Esmolol✓ Raltegravir✓ Spironolactone✓ Colchicine✓ Pilocarpine✓ Baclofen✓ Memantine✓ Clonidine✓ Albuterol✓ Dobutamine

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