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One drug.
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A story-based mnemonic for one drug, every Monday. Built from the drug name itself - so it actually sticks for Step 1 & 2.

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↓ This week’s edition

RxMnemonic Diuretics
Spironolactone
Aldosterone antagonist • K⁺-sparing diuretic • antiandrogen
SPIRONO = spy on aldo + LACTONE = lactate
Separate spironolactone into SPIRONO (sounds like spy on Aldo) and LACTONE (sounds like lactate). Imagine a spy on Aldo, tailing him and blocking everything he does. Aldo is taping holes in the barrel to keep water in, and the spy keeps ripping the tape off to let the water out. Lactone sounds like lactate, your reminder for the classic side effects: lactation and gynecomastia.
Spironolactone
Diuretics SPIRONO = spy on Aldo | LACTONE = lactate
HOW STEP TESTS IT
1
Spironolactone blocks the aldosterone receptor in the collecting duct, so you keep potassium while excreting sodium and water. The most dangerous side effect is hyperkalemia, which worsens with ACEi or ARBs.
2
It blocks androgen receptors, causing gynecomastia and menstrual irregularities, which is what makes spironolactone useful in treating PCOS and hirsutism. It lowers heart failure mortality and is first-line for cirrhotic ascites. 
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Practice Question

A 71-year-old woman with HFrEF and an eGFR of 38 is on lisinopril and metoprolol. Spironolactone is added. Two weeks later, she presents with fatigue and a wide-complex bradycardia. The most likely contributor is:

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One story that makes a drug impossible to forget.

Step 01

It hits your inbox

Every Monday morning, one new drug lands in your email - just the mnemonic, the story, and the clinical pearl.

Step 02

Read the story

A vivid, memorable image helps you remember the drug's mechanism, receptor, and key contraindications in under 2 minutes.

Step 03

Nail the question

Each edition ends with a practice question from last week's drug so you can test yourself.

What's inside

Everything Step tests.
Nothing you don't need.

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The mnemonic breakdown - drug name decoded into a memorable anchor

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The story + image - a scene that burns the mechanism into memory

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How Step tests it - the exact clinical scenarios you'll see on exam day

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A practice question - test yourself on last week's drug before you forget

Drugs covered so far

✓ Spironolactone
✓ Oxybutynin
✓ Finasteride
✓ Vasopressin
✓ Paclitaxel
✓ Aliskiren
✓ Allopurinol
✓ Digoxin
✓ Esmolol
✓ Raltegravir

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One drug.
Every Monday.

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Mnemonic built into the drug name itself
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