Question 1

How do you remember Atropine?

Accepted Answer

Atropine breaks down as AT = acetylcholine + ROPINE = roping. Break atropine into AT (acetylcholine) and ROPINE (roping). Atropine throws a lasso and ropes acetylcholine back, so it can't reach the muscarinic receptors. With acetylcholine roped away, the parasympathetics stop working.

Question 2

What class of drug is Atropine?

Accepted Answer

Atropine is a Muscarinic Antagonist • Anticholinergic • Organophosphate Antidote.

Question 3

How is Atropine tested on the USMLE?

Accepted Answer

Atropine is a competitive muscarinic antagonist. Blocking muscarinic receptors causes the anticholinergic picture: dry mouth, dilated pupils, tachycardia, hot dry skin, urinary retention, and delirium. It is used for symptomatic bradycardia and cholinesterase inhibitor poisoning.

Question 4

A 52-year-old farmer is found confused after spraying crops. He has pinpoint pupils, drooling, wheezing, muscle twitching, and a heart rate of 44. Atropine is given. Which of his findings will atropine NOT reverse?

Accepted Answer

A - Organophosphates block acetylcholinesterase, flooding both muscarinic and nicotinic receptors. Atropine only blocks muscarinic receptors, so it reverses the secretions, bronchospasm, and bradycardia, but muscle fasciculations and weakness come from nicotinic receptors at the neuromuscular junction. Pralidoxime is added to regenerate acetylcholinesterase and address the nicotinic effects.

Atropine

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